This research was conducted to analyze variables which affect the dividend policy. The determination of optimum dividend policy has important meaning for the company because it is related to the profit allocation decision making. This research focused on the financial factors consists of leverage, profitability, liquidity, and growth which are measured by financial ratios because they illustratethe company performances. The variables used in this research are Return on Equity, Debt to Equity Ratio, Asset Growth, and Cash Ratio.The type of this research is explanatory research with quantitative approach. The site of the research used is www.idx.co.id. Data collection technique used is documentation. This research was conducted to all listed companies in LQ-45 index in Indonesia Stock Exchange periods of 2010-2012, the sample are 22 companies. The hypothesis test was conducted by using multiple linear regressions.The results of this research show that ROE, DER, Asset Growth, and Cash Ratio have positive significant influence on Dividend Payout Ratio. ROE has positive significant influence on Dividend Payout Ratio. While DER, Asset Growth, and Cash Ratio have negative significant influence on DPR. The determination coefficient in this research is 68.40%. Return on Equity is the dominant variable in influencing DPR.