This paper focuses on designing, developing and maintaining an E-commerce with Point of sale. Only medical products are available. Some of  the products are First aid kit, Plasters, Cotton wool, Surgical mask, Stethoscope, Oxygen mask, Thermometer, Syringe, Needle, Wheelchair, Stretcher, Scales, Cane, Pill, Dropping bottle, Paracetamol, Amoxicillin, Quinine, Nifedipine, Multivitamin etc., This work would be helpful for customer to buy the products. The rapid growth of technology restructured business transactions and operation. Different computer technologies and the internet empower businesses to centralize their operations and run their business fruitfully. Technological innovations significantly improved business efficiency and overall customer experience and satisfaction. The use of E-commerce platforms and POS system became popular with the emergence of technology and the internet. However, some businesses have not fully adopted the integration of e-commerce and point of sale systems. Some businesses are not fully geared with technology that will help them improve business efficiency, productivity, and customer relationship. This work will allow seamless operation and transaction between business operators and clients. This work will remove the manual process of inputting data of sales, stock and inventory, and payment transaction of customers.