Newborn is considered to be small and incapable, totally dependent on other for lifetime; within one minute of labor the normal new born baby adjusts from a reliant on serious lifespan to an independent one; ready to breathing and carriage on life route. Newborn care is crucial. Clean cord care, thermal care, including drying and covering the newborn vaginal delivery and trying to delay the newborn's first bath for at least 24 hours (sometimes several days to minimize hypothermia risk), and beginning of breastfeeding within the first one hour of birth, management of instantaneous asphyxia, and management of early sepsis are all interventions to reduce newborn morbidity and mortality. Every year, approximately 3 million lives could be saved if evidence-based solutions such as skilled birth attendant care were universally available. Objective: To assess Nurse-midwives' Knowledge about Immediate Newborn Care and to evaluate Nurse-midwives' practice about Immediate Newborn Care. Methodology: A descriptive and analytic design conducted to assess nurses' and midwives' knowledge and to evaluate practices regarding immediate newborn care f. The study was started at 1st of September 2021, to 25th of March 2022. A non-probability (purposive sample) included (50) nurse-midwives who work in Maternity Teaching Hospital's delivery room.