: Socialization skilss training are given to patients with impaired social isolation to practice their skills in relationships with others and the environment optimally that have aims to teach the patients ability to interact with others. The aim of this research is is to know the effect of socialization skills training to the interaction of social pateints' ability. This research method is using the design / pre-experimental study design one group pre test post test. The results is using wilcoxon signed rank test with significant value is 0,000 or less than the significant value of 0,05 (0,00 < 0, 005). Conclusion from the results of this research showed that there is an influence of socialization skills training to interaction capability of social isolation patient in Prof. Dr. V. L. Ratumbuysang Manado. Suggestions socialization skills training can be used as one of the independent actions of nurses in improving the quality of health services to the interaction capability of social isolation patient.