The study made an assessment of professional ethics in secretarial practice and the level of job performance of secretaries. In order to carry out this study, specified research objectives were drawn from which research questions and hypotheses were formulated and used for the study. The research design for this study is a survey design. The population of this study consisted of all the Secretaries, clerks, confidential secretaries, executive secretaries of Uyo local government area council of Akwa Ibom State. The instrument used for data collection was questionnaire. The instrument was validated by two experts. Data from completed questionnaires was subjected to descriptive analysis. The findings showed that there is positive impact of professional ethics in secretarial practice and the level of job performance of secretaries. The study recommended that there is urgent need for a viable professional body to oversee the activities of secretarial professionals in Nigeria. This will go a long way to bring about professionalism in this profession; help regulate and serve as check and balances and bring about the benefits of having a professional body just as in other professions like in health, law, etc. With a viable professional body, all the lapses identified in this study can be resolved.